NATURAL PRODUCTS IN WOUND HEALING: NANO-TECHNOLOGY BASED APPROACHES

Wound is a disruption of the normal anatomical structure and the tissue function. The wound healing or repair is an orderly process which involves multiple phases characterized by inflammation, proliferation and remodeling. Natural products, which are derived from herbs and animals, constitute several chemical compounds which are proven for great wound healing potential. The major issue in therapeutic use of these natural products is the solubility constraint due to high lipophilicity and hence it hampers bioavailability and pharmacological effect. Nanotechnology based approaches are well proven as an approach for solubility enhancement and thus found to be useful for improvement of the efficacy and therapeutic activity. In this review different potential natural products known for promoting angiogenesis and wound healing activity by various mechanisms are summarized with emphasis on the various nanotechnology based approaches developed as a drug delivery system for these products to achieve enhanced solubility and improved its biopharmaceutical properties.