Use of CRISPR to Enhance and Combat Human Viral Infections as HIV and SARS-Cov-2

Viruses depend on organisms to complete their life period, there are many vaccines and antiviral for viruses, but some viruses such as HIV did not show any sensitivity or effect for vaccines or anti-viruses. Recently, researchers are focusing on CRISPR/Cas9, which is a technique that allows for genome editing in organism cells. This technique has changed the concept of genetic engineering and it can be applied to repair genetic disorders in future therapies. Besides targeting the human genome, it can be applied to target specific sites of genetic material for viruses, hence can cure viral infections, and therefore, use to treat SARS-CoV-2 as an emergency solution to treat infections coronavirus, there are increasing numbers of infections coronavirus in the world. Here, we discussed recent studies on the use of CRISPR to enhance and combat human viral infections, with a focus on CRISPR and HIV, CRISPR/Cas9 studies, challenges, and explore mechanisms to apply it in the future. Finally, CRISPR technology is a revolutionary development in engineering resistance against viral infections. But this technique needs more and more studies before applying it to humans.