DESIGN AND EVALUATION OF CONTROLLED RELEASE FLUVASTATIN TABLETS OF LIPID LOWERING AGENT FOR HYPERLIPIDEMIAJournal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.1, No. 5)
Publication Date: 2014-11-06
Authors : Musharraf Ali; Abdullah Khan; Roshan.S;
Page : 359-372
Keywords : Fluvastatin; HPMC; Eudragit S100; guar gum; PVP;
In the present research, an attempt has been made to formulate controlled release matrix tablets of Fluvastatin (FS).Different formulations were prepared by wet granulation method by using different polymers like HPMC K-4M, HPMC E-15, guar gum, eudragit S100, PVP etc. with different ratios were used in the development of formulations. HPMC K-4M, HPMC E-15 and guargum are used as rate conyrolling polymer, PVP used as binder eudragit S100 used as enteric polymer, lactose used as filler, and microcrystalline cellulose as disintegrant. The prepared tablets were evaluated for pre compression and post compression parameters with different ratios. The effect of polymer loading in in-vitro drug release and the mechanism of release was studied by different mathematical models. It can be concluded that among all the formulations the combiFStions of HPMC K-4M and Eudragit S100 was considered as the optimized formulations in the present research work. The optimized formulations show non-fickian diffusion mechanism of release and other all evaluation.
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