STATIN-INDUCED MECHANISMS OF CARBOHYDRATE METABOLISM DISORDERS

Statins are first-line medications that are used to prevent cardiovascular diseases. They reduce the risk of myocardial infarction, stroke, and cardiovascular death by an average of 25-30%. Despite the safety and relative tolerability of statins, observational and clinical studies as well as meta-analyses have shown that statins may increase the risk of developing type 2 diabetes mellitus. Statins have been proven to increase insulin resistance and reduce insulin secretion by pancreatic β-cells.