THE CONTENT OF SULFUR-CONTAINING AMINO ACIDS AND RELATED COMPOUNDS IN THE BLOOD PLASMA OF RATS WITH DIFFERENT TYPES OF ALCOHOL INTOXICATIONJournal: Journal of the Grodno State Medical University (Vol.19, No. 2)
Publication Date: 2021-05-20
Authors : A. K. Semenchuk V. V. Lelevich;
Page : 170-175
Keywords : plasma; intermittent alcohol intoxication; methionine; homocysteine; hyperhomocysteinemia;
Background. Change of the content of sulfur-containing amino acids and their metabolites is one of the pathochemical mechanisms of alcohol intoxication. Purpose of the study. To study the effect of chronic and intermittent alcohol intoxication on the content of sulfurcontaining amino acids and related compounds in the rat blood plasma. Material and methods. Thirty white outbred rats weighing 180-220 g. The content of free amino acids and biogenic amines was determined by HPLC. Results. A 14-day chronic alcohol intoxication was accompanied by a significant decrease in the level of methionine and an increase in the level of homocysteine in the blood plasma. The concentration of glutathione increased by 5%. In the intermittent alcohol intoxication IAI-4 group, the homocysteine content also increased, as did the level of homoserine and cystathionine in the IAI-1 group. Conclusions. Сhronic and intermittent alcohol intoxications cause similar violations of the level of sulfur-containing amino acids and their metabolites in the rat blood plasma.
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