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CHANGES IN IMMUNITY PARAMETERS DURING RADIОTHERAPY FOR HEAD AND NECK CANCER DEPENDING ON THE METHOD OF RADIATION TOXICITY PREVENTION

Journal: Journal of the Grodno State Medical University (Vol.19, No. 2)

Publication Date:

Authors : ;

Page : 212-218

Keywords : head and neck cancer; radiation toxicity; magnetolaser; local hypoxia; cytokines;

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Abstract

Background: The use of magnetolaser and local hypoxia during radiotherapy for head and neck cancer leads to decrease in acute toxicity. Purpose: To reduce the severity of acute toxicity in patients with head and neck cancer using the developed methods of prevention. Material and Methods: A prospective randomized study included 120 patients with head and neck cancer. A comparative assessment of the effectiveness of the three developed methods of prevention was carried out in comparison with traditional prevention. Results: The use of magnetolaser, local hypoxia and their combination led to decrease in the level of pro-inflammatory cytokines and increase in anti-inflammatory cytokines as compared with the control group. This corresponded to a lesser degree of acute toxicity in the main groups. Conclusions: The use of magnetolaser and/or hypoxia reduces acute toxicity, which is confirmed by changes in immunity parameters.

Last modified: 2021-05-20 20:35:20