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Regioselective One-pot transformation of 2’-hydroxy chalcones to 3,5-diphenylisoxazole via dehydrogenation of dihydroisoxazolines using Copper salt in DMF

Journal: Journal of Applied Organometallic Chemistry (Vol.1, No. 2)

Publication Date:

Authors : ;

Page : 59-65

Keywords : dehydrogenation; Cu salt; 2’ -hydroxy chalcones; 3; 5-diphenylisoxazole; dihydroisoxazolines;

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A synthesis of series of 3, 5-diaryl isoxazoles has been described. The Cu salt in DMF with EDU base induces oxidative dehydrogenation of 2-(5-phenyl-4,5-dihydroisoxazol-3-yl) phenol results in the formation of 2-(5-phenylisoxazol-3-yl) phenol in excellent yields under mild reaction conditions. The present protocol contains cheap catalyst, easy workup, normal reaction conditions and high selectivity.

Last modified: 2021-06-23 14:42:44