Comparison of Magnesium Sulphate 100mg and Fentanyl 25µg as Adjuvants to Intrathecal Hyperbaric Bupivacaine 0.5% for Infraumbilical SurgeriesJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 1)
Publication Date: 2021-01-05
Authors : C. P. Huda; S.P. Chittora; Rakesh Choudhary;
Page : 140-142
Keywords : fentanyl; meganisium sulphate;
Introduction: Intrathecal adjuvants have gained popularity for prolonging the duration and quality of block; opioids (fentanyl and sufentanil) and other drugs like magnesium sulphate, midazolam, clonidine and ketamine are used. Methods: We conducted double blinded, prospective study on total of 90 patients, who were randomly allocated into three groups. Inclusion Criteria: 1. ASA grade I&II. 2. Patients of either gender between ages of 18-60 years. Exclusion Criteria: 1. Patients with severe systemic disease - hepatorenal, cardiovascular diseases and bleeding disorders. 2. Patients with allergy to opioid. Discussion: In our study, it was observed that Bromage score 3 was achieved earliest in group C in 10 min while in other groups it was delayed. Ozalevli et al. observed a similar delay when adding intrathecal magnesium to fentanyl and isobaric bupivacaine (we used hyperbaric bupivacaine in our study Conclusion: Addition of magnesium sulphate at 100 mg dose or fentanyl 25 ÃŽÂ¼g as adjuvants to intrathecal bupivacaine significantly prolongs the duration of analgesia. At these doses, magnesium provides better haemodynamic stability than fentanyl, with fewer side effects. References: Ozalevli M, Cetin TO, Unlugenc H, Guler T, Isik G. The effect of adding intrathecal magnesium sulphate to bupivacaine-fentanyl spinal anaesthesia. Acta Anaesthesiol Scand 2005; 49: 1514-9.
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