5 Alpha - Reductase and Metabolic Syndrome in PCOS Patients

Objectives: Polycystic ovary syndrome is one of the most common endocrine pathologies in fertile women. PCOS is an endocrine disorder characterized by a disorder of the reproductive and metabolic systems that include hyperandrogenism, ovarian dysfunction and morphological changes in the ovaries (presence of cysts) as well as other clinical and biochemical symptoms such as hirsutism, hyperinsulinemie, etc. alpha reductase deficiency is considered one of the causes of PCOS and total testosterone/dihydrotestosterone ratio (TT/DHT) it is used in the evaluation of its activity.Methods : In 70 cases diagnosed as PCOS, based on Rotterdam criteria we measured the serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone (TT) and DHT. TT/DHT ratio was calculated in order to reflect 5alpha-reductase activity. In all participants, anthropometric data, lipids, HOMA-IR were also assessed.RESULTS: In cases of PCOS patients we measured the level of TT (0.87±0.79 ) (ng/ml), DHT (29.9±11.8) (ng/dl), FSH (5.7±2.06) (UI/L ), LH ( 12.7±10.2) (UI/L ). We calculate LH/FSH ratio ( 2.3±1.2) and TT/DHT ratio (3.1±1.7 ).PCOS patients showed significantly higher levels of TT than control group. The TT/DHT ratio was significantly higher in PCOS patients (P