Analytical Correlation of D-dimer as Coagulation Biomarker with C-Reactive Protein, Neutrophil Lymphocyte Ratio, and Absolute Lymphocyte Count as Inflammatory Biomarker in COVID-19 Patient: A Retrospective Study

Background and aims: COVID-19 is an infectious disease cause by SARS-CoV-2 virus. Coagulophaty and Thrombotic complication frequently occur in COVID-19 patient. Both coagulation and inflammatory biomarker were elevated in COVID-19 and associated with severity of disease progression. This article aims to explore the correlation of D-dimer with Inflammatory Biomarker in COVID-19 patient, this inflammatory biomarker include C-reactive protein (CRP), neutrophil lymphocyte ratio (NLR) and absolute lymphocyte count (ALC). Methods: This Study is a restropective observational analytical study with crossectional design using secondary data of medical record patient conducted at Wangaya Hospital, Denpasar between July 2020 and Desember 2020. Data that meets inclusion criteria were included in this study and restropectively analysed. Result: Kolmolgorov Smirnov normality test D-dimer, CRP, NLR and ALC were not normaly distribute (p < 0.001 ; p < 0.001 ; p < 0.001 and p=0.004 consecutively). Spearman Correlation test we found significantly positive correlation of D-dimer concentration with CRP and NLR ( r=0, 825, p < 0.001; and r= 0.735, p < 0.001 consecutively), but D-dimer with ALC were found to be significantly negative correlated ( r=-0.591. p < 0.001). Conclussion: Elevated concentration of D-dimer serum were correlate with inflammatory biomarker in COVID-19 patient. This finding may suggest that inflammation is one of the factor that causes activation of coagulation in COVID-19 patient