Non Alcoholic Fatty Pancreatic Disease Significance, Importance and Risk factors

Globally, diabetes mellitus (DM) is the third most common noncommunicable disease. Nonalcoholic fatty pancreas disease (NAFPD), is a disease characterized by pancreatic fat infiltration or pancreatic islet cell steatosis. The present work aimed to determine the prevalence of NAFPD among obese with and without DM, it is emerged as mirror image of NAFLD because of the same embryological origin. Evaluation of associated risk factors. Methods: This was cross sectional study among conducted on (200) subjects. The study protocol was presented to the ethical committee of Al-azhar faculty of medicine for approval. All subjects were subjected to the following: History, clinical examination and laboratory investigations including (Serum Insulin level, HOMA-IR and Fatty Acid Binding protein1 (FABP1). Imaging: (Abdominal Ultrasound and EUS). Results: Prevalence of NAFPD was 37 % among all of the studied sample. There was a significant relationship between NAFPD and T2DM. Mean value of BMI, Hb A1C and HOMA IR were statistically higher among Cases with NAFPD than Cases without NAFPD. There were statistically significant positive correlation between Fatty Acid Binding Protein I (F ABPI) and BMI. Conclusion: there is a significant association between the presence of nonalcoholic fatty pancreas disease and diabetes mellitus. Positive statistically significant correlation between insulin resistance and NAFLD. Positive correlations between plasma FABP1 levels and (BMI and HbA1c). FABP1 has a good diagnostic value in nonalcoholic fatty pancreas disease cases.