Assessment of Analgesic Activity of the Extract of Sesbania genus Plants in Animal Models

The objective of this study was to evaluate the analgesic activities of the hydro-alcoholic extract of the leaves of Sesbania grandiflora and Sesbania bispinosa individually and in 1: 1 combination, and an analgesic effect of different fractions in animal models. The analgesic effect was examined by Eddy’s hot plate model. Application of different doses of Sesbania genus plants and their combinations had significant analgesic effects on Eddy’s hot plate edema model. The findings showed that all the Sesbania genus plants and their combinations at given doses of 250 and 500 mg/Kg demonstrated analgesic activity. Plant extracts with 1: 1 Combination has shown better analgesic activity than individual plant extract and are comparable with Pentazocine. This study demonstrated the analgesic effects of Sesbania genus extracts in animal models and supports traditional use of this plant in the treatment of pain management More studies are required to identify the active components.