Primary Bone Non-Hodgkin's Lymphoma: A Literature Review

Primary Bone Lymphoma (PBL) according to the World Health Organization (WHO) is a single skeletal lymphoma with or without lymph node involvement and multiple bone lesions without visceral or lymph node involvement. The etiopathogenesis of this disease remains unclear and requires further research. Literature search was done using search engines from Pubmed, Google Scholar, Cochrane Library, Web of Science, popular premier orthopedic journals (JBJS, BJJ, CORR, INJURY, ABJS, ActaOrthopedica, IJO) and general medical journals (JAMA, NEJM, Lancet) in the last 5 year, but relevant older articles were included. The diagnosis of PBL is confirmed by clinical examination, radiological support and biopsy. Standard management to date includes immunochemotherapy with or without radiotherapy, while operative measures are limited to biopsy sampling and stabilization of pathologic fractures or impending fractures with risks above intermediate. A good prognosis is found in PBL patients with Diffuse Large B Cell Lymphoma. Until now, due to the rarity of the disease, there are very few studies that discuss PBL and its associated management as guidelines in determining therapy and prognosis. This study describes the related PBL, especially PBL with Non-Hodgkin's lymphoma.