A Study of Outcome of Shorter MDR-TB Treatment Regimen on Multidrug Resistant Tuberculosis Patients under RNTCP

Background: Shorter MDR-TB (Multi Drug Resistant)Regimen is widely used for Pulmonary MDR Tuberculosis patients and there is much less data regarding the outcome of this regimen. Material and Method: The study is record based. The study enrolled 50 MDR PTB patients started on shorter MDR-TB regimen at department of Respiratory Medicine, Sir T Hospital, Bhavnagar from April 2018 to December 2018.Data regarding follow up sputum smear, sputum culture and outcome of patients started on shorter MDR regimen was collected from DTC Bhavnagar. Observation: ? Out of 50 patients enrolled in the study, 52% (26/50) patients completed the regimen, 26%(13/50) patients defaulted the treatment and 22%(11/50) died during the study. ? 23% (6/26) had positive end IP culture and 77% (20/26) had negative end IP culture. ? 23% (6/26) had positive end CP culture, 58% (15/26)had negative end CP culture and end CP culture were not sent in 19% due to change of regimen. ? 19% (5/26) reported FQ resistance, 4% (1/26) reported SLID resistance. ? 30% (15/50) patients were cured, 12% (6/50) had treatment failure, 10% (5/50) were put on newer regimen. Conclusion: Even though Shorter MDR regimen is cost effective and of short (9-11 months) duration, outcome of Shorter MDR regimen depends on patient?s compliance and pattern of resistance to second line drugs.