Comparison of Intrathecal Clonidine and Neostigmine with Intrathecal Bupivacaine for Lower Abdominal Surgeries

Background and Aims: Use of adjuvant drugs in SAB prolongs the duration of the action. This study was conducted to compare the effects of intrathecal clonidine with neostigmine added to hyperbaric bupivacaine intrathecally, with regards to sensory characteristics, motor characteristics, haemodynamic parameters. Methods: This was a prospective randomized double blind study in 50 patients of ASA grade I and II status and aged between18 to 60 years. First group received intrathecal Clonidine 75 ?g and 3 ml (15 mg) of intrathecal 0.5% hyperbaric bupivacaine (group C) and second group received neostigmine 50 ?g with 3 ml (15mg) of intrathecal 0.5% hyperbaric bupivacaine (group N) . Results:Addition of 50 ?g neostigmine hastened the onset of sensory block (N - 96 ?12 secs, C-150 ?14 secs, P value as