Study on Spot Urine Protein Creatinine Ratio in Preeclampsia as an Alternative for 24 Hour Urine Protein

InformedConsent?Informed consent was obtained from all individual participants included in the study. Abstract:Aim:Determination of diagnostic accuracy of spot protein creatinine ratio in comparison with 24hour urine proteinuria, evaluation of protein creatinine ratio for different proteinuria ranges in patients with preeclampsia and estimation of protein creatinine ratio for significant proteinuria in suspected preeclampsia.Design: observational study. Method:study was conducted on Department of Obstetrics and Gynaecology, SRN Hospital M. L. N. Medical College, Allahabad. Study was conducted on 150 pregnant women with greater than20 weeks of gestation with blood pressure more then 140/90 mm of mercury instructed to collect 24hour urine protein over 1 year from august 2017 to 2018.Protein creatinine ratio was evaluated in a random urinary sample. Relationship of spot urine protein creatinine and 24hour urinary protein, accuracy of the ratio against 24hour urinary protein and relationship of such ratio and adverse pregnancy outcome were studied. Result: The optimal cut off value of spot protein creatinine ratio for significant proteinuria was 0.27 at which sensitivity was 88.1% and specificity was 98.1% with positive predictive value of 97.36 % and negative predictive value of 91.37%. CONCLUSION: A definite correlation was found between 24hour urine protein and spot urine protein creatinine ratio which was statistically significant (r=0.9668. P value