Assessments of Sero-Detection of HEV Antibodies IgG and IgM among Spontaneous Recurrent Miscarriage Women Case Control Study in Gezira State 2018

Background: Recurrent miscarriage is a critical problem and it takes to increase during current decade, HEV virus has relation with recurrent miscarriage according to some previous study conducted in many countries. Objectives: The aim of present study to Sero-detection of HEV virus (IgG and IgM antibodies) by using ELISA techniques among women with recurrent miscarriage in Gezira stateand assessment of other risk factors according to questionnaire. Method: Analytic - case control study (45women in each arm) was conducted at Wad Madani teaching hospital Department of Obstetrics gynecological, AlGezira state, Sudan. The cases were women with recurrent miscarriage and controls were healthy pregnant women (non-miscarriage). HEV antibodies were analyzed in the sera of the entire participants using ELISA techniques. Results: Ninety women were enrolled in each arm of study. Miscarriage serum IgGsero-positivity for HEV(31.1% vs.28.9%) and borderline(6.7%) vs. 4.4%) by ELISA.There were no significant difference inmiscarriage serum IgMSero-positivity for HEV(4.4%vs. 2.2%) and borderline (2.2%) by ELISA. In logistic regression analysis of the predictors for miscarriage (OR=1.8,95%CL=1.8-2.1, P value 0.000 ) IgGSero-positivity were at risk for miscarriage ,Other significant risk factors include micreocytichypochromicanaemia, vaginal bleeding, pre-eclampsia and family history. Conclusion: In the current study HEV IgG and IgMsero-positivity is associated with miscarriage. Using ELISA techniques are presumptive tools to confirm the results. Preventive measure should be implemented. Further research in needed. Keywords: HEV antibodies, recurrent miscarriage women, ELISA