Role of Serum Vitamin D in Preeclampsia and Eclampsia

Abstract:Aim:tostudy the association of low serum vit.D. level as a risk factor for preeclampsia and eclampsia ,asses the predictive value of hypovitaminosis D for preeclampsia and eclampsia .and to compare the vit.D levels in pregnant women complicated with preeclampsia /eclampsia and with normal pregnancy .Design: observational study. Method:study was conducted on Department of Obstetrics and Gynaecology, SRN Hospital M. L. N. Medical College, Allahabad. Study was conducted on 150 pregnant women with larger than20 weeks of gestation with blood pressure more then 140/90 mm of mercury. s.calcium level -measured by random access biochemistry autoanalyzer . Vitamin D Calculation :done by architect plus immunoassay autoanalyzer in pathology department of swarooprani hospital.result: Mean significant S.vit.D level of cases was significantly lower than controls (P value less than0.001). Mean s.calcium level of cases was significantly lower than controls.( P value less than0.001). Mean S.vitamin D level was significantly lower in eclamptic patients than preeclampsia. Conclusion Study shows significant association of low serum vit.D level with preeclampsia and eclampsia considered as modifiable risk factor Vit D supplementation in early pregnancy should be explored for preventing preeclampsia and promoting neonatal wellbeing . vitamin D support in patients with a history of preeclampsia in previous pregnancies may decrease the risk of preeclampsia and eclampsia during the current pregnancy