Formulation and In-vitro Evaluation of Diltiazem Hydrochloride Non Effervescent Floating Tablets

In the present research work non effervescent floating formulation of Diltiazem hydrochloride by using various polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. . Then the formulation was developed by using different concentrations of polymers of various polymers. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulation F7 prepared by using Chitosan 10 mg produced maximum drug release compared to other formulations hence it was considered as the optimized formulation. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed zero order kinetics of drug release.