Pharmacognostic, Phytochemical Standards and Antiulcer Activity of Aqueous Extracts of Annona Squamosa and Annona Reticulata Leaves Onrats

The present work was undertaken to establish the pharmacognosticphytochemical standards and anti-ulcer activity of aqueous extracts of leaves of Annona squamosa Linn. and Annona reticulata Linn on wistar rats by pyloric ligation method. These are highly apparent plants in ayurvedic system of medicine for the treatment of various ailments. A. squamosa Linn. and A. reticulata Linn. are locally known as Sitaphala and Ramphal respectively both belongs to family Annonaceae. The plants are traditionally used for the treatment of epilepsy, dysentery, cardiac problems, worm infestation, constipation, haemorrhage, antibacterial infection, dysuria, fever and ulcer. In model the common parameter determined was ulcer-index. aqueous extracts of dosage 175, 350 mg/kg p. o produced significant inhibition of gastric lesions induced by pyloric ligation induced ulcers The extract 175mg/kg & 350mg/kg indicate that the aqueous extracts significantly (P less than 0.001) decreases the volume of gastric acid secretion, PH, free acidity, total acidity and ulcer index compared to control. This present study indicate that leaves extracts have potential antiulcer activity. This result may further suggest that aqueous extracts were found to posses anti ulcerogenic as well as ulcer healing property. No reports are available on the pharmacognostic nature, phytochemical and anti-ulcer activity studies of the both plant leaf. Hence, the present study was carried out to investigate the same. All the parameters were studied according to the WHO & Pharmacopoeial guidelines. This parameters will help for correct identification of these plants for the future references.