Correlation Of Spot Urine Protein Creatinine Ratio With Angiographic Disease Severity In Non-Diabetic Stable Coronary Artery Disease

Background: Coronary artery disease (CAD) is a major cause of death and disability. Microalbuminuria, a marker of atherogenesis and early endothelial damage has been an emerging risk factor. This study aimed to correlate urine spot protein creatinine ratio with angiographic disease severity in non-diabetics with stable coronary artery disease. Methods: This was a single center prospective observational study which included 100 non-diabetic patients with stable CAD. Spot urine protein creatinine ratio was used to define Microalbuminuria (MA) (30-300mg/g creatinine), and severity of CAD was estimated using SYNTAX score and Modified Gensini score. Patients were divided into two groups: one group included patients with out MA and another group included patients with MA. Results: Out of 100 non-diabetic patients with stable coronary artery disease, 56 (56 %) were in MA negative group and 44 % were in MA positive group. The mean age of the study population was 58.65±9.7 years with majority of them being males (75 %). The prevalence of double vessel CAD and triple vessel CAD was significantly higher in MA positive group compared with the MA negative group (79.54 % vs 26.78 % p less than0.00002). MA positive group when compared with the MA negative group had majority of them with High SYNTAX score (77.27 % vs 8.9 % p less than 0.00001) and also high Modified Gensini score were observed in MA positive group compared to MA negative group (84.8 % vs 25 % p less than 0.00001). Statistically significant positive correlation was seen between urine protein creatinine ratio and SYNTAX score (r = 0.650, p less than0.0001) and even with Modified Gensini score (r = 0.697, p less than0.0001). Conclusion: This study concludes that non-diabetic patients with microalbuminuria have more severe angiographically detected CAD than with out microalbuminuria, hence enlightening the role of microalbuminuria as an independent risk factor for CAD in non-diabetics.