Utility of Immunohistochemical Markers in the Diagnosis of Small Cell Neuroendocrine Carcinoma Cervix - A Case ReportJournal: International Journal of Science and Research (IJSR) (Vol.9, No. 4)
Publication Date: 2020-04-05
Authors : Dr Kalaranjini K V; Dr Sheelavasudevan; Dr Limi Mohandas;
Page : 1270-1272
Keywords : SCNEC; aggressive; immunohistochemistry;
Neuroendocrine carcinoma (NEC) of cervix is an aggressive histological variant of cervical cancer accounting for about 1-1.5 % of all cervical cancers. High grade ( G3) neuroendocrine carcinoma are highly aggressive tumours and frequently present at an advanced stage. Immunuohistochemical staining for neuroendocrine markers provide support for diagnosis. The 5 year survival for small cell neuroendocrine carcinoma (SCNEC) of all stages reported to be 14-39 % with poorer survival in higher stage disease. The management of high grade neuroendocrine carcinoma may include specific neuroendocrine based systemic chemotherapy and radiotherapy including axial sites.
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