Clippers - A Rare Treatable Neuro Inflammatory Disorder of Brainstem: A Case Report and Review

Aim: To bring attention to uncommon such treatable neuroinflammatory condition. Introduction: CLIPPERS (Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids) is a rare immune mediated inflammatory central nervous system (CNS) disorder, prominently involving the brainstem and in particular the pons. It is characterized by Perivascular and T cell-predominant inflammatory cell infiltration in affected CNS lesions and responsive to steroids. Case Report: We are reporting case of 18 year old female who presented with two months history of gradually progressive disequilibrium, diplopia, dysarthria, nystagmus, right lower motor neuron palsy with decrease taste sensation. Patient was investigated and treated accordingly and clinical improvement was seen 5 days after the initiation of the therapy. Conclusion: CLIPPERS is a newly described pontine-centric inflammatory disorder with distinct clinical and radiological features which is completely curable with steroids. All physicians should be aware of such treatable neuro inflammatory condition. Clinical Significance: This highlights the fact that as CLIPPERS is treatable, in whom the cause of their clinical features could not be recognised may help in improving the outcome considerably in these cases.