Determination of the C-LDL SERIC Concentration Comparison of a Direct Method and the Formula of Friedwald

Introduction: LDL cholesterol (C-LDL) is the essential lipoprotein marker in assessing the risk of atherosclerosis. In common practice, it is estimated by Friedewald's formula. The objective of this study is to compare the determination of this biochemical parameter using the Friedwald formula against the direct dosage. Patients and methods: This is a cross-sectional study, comparing the results obtained by the direct dosage of C-LDL to those estimated by the Friedwald formula. The data collection was done randomly in accordance with the criteria for including the required variables. The statistical analyses were carried out on the SPSS V10 software at the risk of 5%. Results: A total of 447 patients included 259 (58%) diabetics and 188 (48%) non-diabetics. The median age of the population was 54 [45-64] with a male predominance 54% (S/R H/F-1.1). The average levels of total cholesterol and HDL cholesterol were 1.77 -0.45g/L and 0.44 -0.11g/L, respectively, the median glycerid level was 1.15 [0.87-1.52] g/L. There was no statistically significant difference between the average serum concentrations obtained by the methods studied, the average cholesterol-LDL per calculation of the Friedewald formula was 1.08 - 0.38g/L versus 0.97 - 0.37 g/L of dosed C-LDL (p -0.05). Conclusion: Variations in triglyceride concentrations and total cholesterol showed no impact on LDL-cholesterol values for each of the methods studied.