Pathogenic Mechanism of Diabetic Retinopathy

Diabetic retinopathy is the leading cause of blindness in industrialized countries. Pathogenetic changes in retinal microvessel structure as diabetic retinopathy is a major cause of structural changes include thickening of the capillary basement membrane, loss of perisit retina, increased vascular permeability, and the formation of capillary microaneurysms. Structural changes were accompanied by a decrease in retinal blood flow, angiogenesis, capillary occlusion, bleeding, formation of tissue fibrosis, and tractional retinal detachment. Some events, or all of the combinations of events, can eventually cause damage to or total loss of sight. This study gives an overview how the pathogenic mechanisms of diabetic retinopathy.