Investigation of Anti-Tubercular Potential of Dalbergia spinosa Roxb., Root Extracts

Dalbergia spinosa Roxb. (Family: Papilionaceae), is a large shrub with a tendancy to climb. Root is having bitter taste, used to treat inflammations, urinary problems, pain and fever cases. Dalbergia spinosa have been reported for various pharmacological properties such as hypothermic, spermicidal, semen coagulant, hypoglycemic, cardio vascular, antimicrobial, diuretic and analgesic. The main objective of the present study is to evaluate anti-tubercular activity against Mycobacterium tuberculosis H37Rv using Dalbergia spinosa Roxb. , root extracts in different doses, in order to combat the emergence of multi drug resistant tuberculosis caused by allopathic drugs. Phytochemical screening revealed the presence of Polyphenols, flavonoids and isoflavones, proteins. Dalbergia spinosa, Roxb. , root extracts were exhibited significant anti-tubercular activity against M. tuberculosis H37RV at the MIC of 50µg/ml, by using Isoniazid as a standard, 0.025µg/ml.