Estimation of Lipid Peroxidase&Micronucleus Status in Oral Cancer

Introduction: Oral cancer is caused by the consumption of tobacco, cigarettes, but even those who do not consume it are likely to have cancer (OnlymyhealthEditorial team, 2011). It is one of the most common types of cancer worldwide and in India it is the second most common cancer after lung. In Madhya Pradesh, it is the most common type of cancer. This highest incidence of mouth cancer in central region in India can be attributed to tobacco use in Central India. There is an alarming need to look for diagnostic measures for its early and effective treatment. Biochemical analysis of oral cancer patients by estimating lipid peroxidase and genetic damage by micronucleus assay can be good predictor of cancer and can be used for diagnosis as well as prognosis. The present review work explores the various studies done on the utility of biochemical and genetic analysis in oral cancer patients with regard to lipid peroxidase level to check for oxidation stress that can lead to cancer and micronucleus assay to look for genetic damage in cancer. Method: PubMed, Cochrane data were explored for relevant studies by through electric search and the selected studies were analyzed and summarized for clarification and providing more insight into the subject. Results: A number of studies have been done in the above-mentioned topic and have supported the role of these biochemical and genetic assays in determining cancer risk.