Echocardiography Based Study of Diastolic Dysfunction in Children with Asymptomatic ?eta- Thalassemia Major and its Correlation with Serum Ferritin

This was an observational cross sectional study of 96 Patients at R. G Kar Medical College and Hospital, Kolkata. with diagnosis of β Thalassemia major children aged between 2-12 years between 1st March, 2016 to 28th February, 2017. A control group of 100 normal subjects matched according to age and sex, with the cases were also studied. Patients who fulfil the inclusion and exclusion criteria were enrolled for the study after getting written informed consent. Echocardiography study was done of all the patients for assesment of diastolic function and determined whether it has any correlation with serum ferritin level in asymptomatic β Thalassemia major. It showed 66.67 % of children were suffering from diastolic dysfunction, most of them were in grade 1 diastolic dysfunction followed by grade 3 diastolic dysfunction. The grade of diastolic function was correlated to the serum level of ferritin