A Report of Two Cases Type 2 Diabetes Mellitus in Children

Background: Type-2 diabetes mellitus (T2DM) was initially considered an adult entity. The case has now been reported in children in developed countries because of the increased incidence of obesity and sedentary habits associated with lifestyle changes. T2DM was diagnosed based on the absence of ketosis, good beta-cell reserve, as shown by the C-peptide assay, the absence of insulin autoantibody, and response to oral hypoglycemic agents. Objective: These case reports aim to describe clinical characteristics, management, and social aspects of T2DM in children. Case: The first case, a 12-year old female with a familial history of T2DM, presented with a history of weight loss for the past year. She also experienced vulvovaginal candidiasis. Her initial laboratory results upon admission were 14.5 % HbA1C and 1.3 ng/mL C-peptide. The second case was an obese, 10- year old female who presented with frequent urination for the past six months. Her mother experienced gestational diabetes in the past. Her laboratory results upon admission were 10.7 % HbA1C and 2.4 ng/mL C-peptide. Both cases were managed well by long-acting insulin and oral metformin. Systematic screening and evaluation management of T2DM is essential for clinicians. These include additional focus on lifestyle management and familial support. For patients with obesity, efforts targeting weight loss, including lifestyle modification and medication, are recommended to prevent complications.