Antihistamine in Pediatrics Dermatology

Antihistamine commonly used in cases of pediatrics dermatology. Skin diseases are generally found in at least 30 % of all visits to pediatrics clinics. Pediatrics population is heterogeneous, which range from preterm neonates to adulthood after puberty. Each group has a higher complex physiological, developmental and psychological characteristic than the adult population, this description varies widely from neonates to adulthood. H (1) -antihistamines are generally used to relieve itching and other symptoms due to atopic dermatitis, urticaria, allergic rhinitis, or other diseases that have high morbidity in children. H (1) -antihistamines can be categorized into first-generation and second-generation antihistamines. The first generation H (1) -antihistamines penetrate the blood brain barrier and thus have a significant effect for the central nervous system giving them a sedative effect. The adverse effect of H (1) -antihistamines such as sedation, central nervous system disturbances, gastrointestinal complaints, anticholinergic effect, cardiac arrhythmias, moreover hypersensitivity reactions. Second generation of H (1) -antihistamines are the drugs of choice for allergic responses because of their high selectivity to H1 receptors, high efficacy, and minimal side effects. The half-life in plasma depends on drug metabolism and elimination processes in the body. The process is the same in children and adults, but it is said to occur more rapidly in several cases of children with certain antihistamines. Adverse reaction in children reported against multiple antihistamine administered, although antihistamine is an important drug for use, should not forget that antihistamine also can cause severe reaction and not completely safe drugs.