The Corpus Callosum Agenesis, Antenatal Diagnosis: A Case Report, 2018, Kingdom of Saudi Arabia, Eastern Region, Alahsa

Background: Corpus callosum agenesis is a congenital abnormality that can be partial or complete. It is reported to have an incidence of about 1: 4000 live births. This case of corpus callosum is reported as the third incidence on the family. It was detected antenatally by the sonographic study. Case presentation: A 33-year-old married female gravida3 para2 living0, referred to perinatology clinic at 12 weeks and two days of gestation due to a history of congenital anomalies. In 22 weeks plus two days of gestation the ultrasound revealed typical signs of corpus callosum agenesis: dangling choroid plexus, teardrop sign (highly suggestive of agenesis of corpus callosum), and absent cerebellar vermis. The outcome of this pregnancy is a preterm baby girl with congenital anomalies and dysmorphic features; cranial ultrasound showed complete absences of the corpus callosum. Conclusions: The baby girl is admitted to maternity and children hospital under observation and for further intervention seeking for symptomatic relief. The case is reported to cytogenetic center at Dammam for further genetic analysis. We are reporting this case in the literature to raise any association since it is the third incidence of congenital anomaly in the same family since there is no previous incidence has been reported in Kingdom of Saudi Arabia.