A Study on Endometrial Carcinoma Cases in a Tertiary Care Centre

Endometrial cancer is the most common malignancy of female genital tract in US. Common in postmenopausal women with mean age of 65 years. Aim: To study histological type, grade, surgical stage of endometrial cancer. Correlate pre and postoperative grades with nodal metastasis. Methodology: Retrospective and Prospective study of 106 cases of endometrial carcinoma was done. Required data was collected from medical records department for retrospective cases. Specimen were received, processed and studied in prospective cases using routine H& E stain. Histological grades were grouped into two groups. Well differentiated and moderately endometrial carcinoma as Group I. Poorly differentiated and undifferentiated as group II. Chi square test was used to correlate groups (pre and postoperative) and nodal metastasis. Observation and results: Most common histological type is Endometrioid carcinoma (grade 1) with mean age of 55 years. Presented as postmenopausal bleeding with or without vaginal discharge.76.42 %, 9.43 %, 6.60 %, 2.83 % and 4.72 % of cases presented in FIGO Stage IA, IB, Stage II, Stage III C1and IIIc2 respectively. Significant correlation between grade 3 and UDC (group II) and nodal metastasis with p valve of 0.000016 and 0.000002 (pre and postoperative) respectively. Conclusion: High grade tumours show significant correlation with nodal metastasis when compared to low grade. In high grade tumours, staging surgery with wide nodal excision improves survival.