Resistin: A New Link in the Old Tale

Adipocytokines are cytokines secreted mainly by adipose tissue that play an important role in various metabolic functions such as short and long term energy homeostasis. Resistin is one of the most important adipocytokines implicated in insulin resistance. Chronic inflammation mediated by resistin can lead to some metabolic disease such as obesity, atherosclerosis, and cardiovascular diseases. Recent studies have shed light on the correlation between obesity and periodontitis and resistin has been suggested on the molecular link connecting periodontitis, obesity and diabetes mellitus. An online search was conducted for relevant literature published in English between 2000 and 2018 using MEDLINE/Pubmed database. Resistin, obesity, insulin resistance, periodontal disease and periodontitis were the search terms used. The relevant articles were chosen and compiled. This literature review provides an insight into the possible role played by resistin in linking periodontitis and various systemic diseases/conditions.