Evaluation of Antioxidant Activity of Pomegranate Peels Phytosome

Phytosomes are novel phytophospholipid carriers for herbal drug delivery as standardized extracts which are shows, poor bioavailability and limited clinical utility. Pomegranate fruit (Punica granatum L. ) belongs to the Punicaceae family is one of the most popular and important horticultural fruits, which contain high levels of a diverse range of photochemical including polyphenols, sugars, fatty acids (conjugated and non-conjugated), aromatic compounds, amino acids, tocopherol, sterols, terpenoids, alkaloids, etc. It has been proved that pomegranate has a high antioxidant activity and is effective in the prevention of atherosclerosis, cancer, cardiovascular disease, dental conditions, bacterial infections and antibiotic resistance, and ultraviolet radiation-induced skin damage. The objective of this study to compare the antioxidant activity of methanolic extract of obtained from pomegranate peels and its Methanolic extract-phospholipid complex (ME-PC) phytosomes. Aqueous solutions of known Fe+2 concentrations, methanolic extract of pomegranate peels and prepared phospholipid complex were used for calibration. It was found that the methanolic extract- phospholipid complex i. e. prepared Phytosomes has higher antioxidant activity than methanolic extract.