Difference Expression of Galectin-3 in Various Depth of Invasion on Colorectal Adenocarcinoma in RSUP Sanglah Denpasar

Colorectal carcinoma is the fourth leading dead of malignancy in the world, including Indonesia. The depth of invasion is one of the major prognostic factors. Galectin-3 is one of the markers that are involved in anti-apoptosis, cell adhesion, and various mechanism, such as survival, angiogenesis, proliferation, transformation, and cell migration. The purpose of this study was to determine the role of galectin-3 in depth of invasion of colorectal carcinoma. This study used analytic cross-sectional method. Forty-five samples were selected from adenocarcinoma NOS by proportional stratified random sampling. Re-diagnosis was carried out to determine depth of invasion, followed by immunohistochemical staining of galectin-3 that performed at Sentra Diagnostik Patologi Bali Laboratory. Data were analyzed by One Way Anova and Chi-square test with a value of p