Profile of Coronary Artery Disease in Patients of Hypothyroidism in a Tertiary Care Hospital of Central India: An Observational Study

Hypothyroidism or Thyroid dysfunction to be more precise affects the cardiovascular system in varied forms. Acting through multiple octopus arms, hypothyroidism weakens the heart per se. The most dreaded mode of resilient injury is an accelerated atherosclerosis. Other mechanisms being a dyslipidemic and procoagulant state, endothelial dysfunction and diastolic hypertension. In this study, cardioascular profiling of patients with diagnosed hypothyroidism was undertaken and the pattern was analysed. Stable ischaemic heart disease was the most common presentation, with varying degrees of diastolic dysfunction being much frequent as compared to systolic dysfunction. Coronary pathology fell concordant with the clinical picture and a strong association was found between poorly controlled hypothyroidism (TSH greater than 20mIU/l) and the extent of coronary artery disease.