Dress Syndrome - A Rare Presentation of Phenytoin Hypersensitivity

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threatening syndrome characterized by skin rash, fever, lymph node enlargement, and involvement of internal organs. It is most commonly induced by aromatic anticonvulsants and antibiotics. Nonaromatic anticonvulsants are rarely encountered as the causes of DRESS syndrome. We report one such case of DRESS syndrome due to phenytoin (Aromatic) anticonvulsant intake in 46 years old male of seizure disorder. He developed symptoms after 4 weeks of start of the treatment. He recovered after change of anticonvulsant and short steroid course.