Evaluation of Cervico-Vaginal Fluid Prolactin in Premature Ruptured Membranes

Premature rupture of membranes (PROM) is one of the most common complications of pregnancy that has a major impact on pregnancy outcome. The assessment of women with possible membrane rupture is a management issue that is faced in every day practice. This prospective case control study was conducted at Karama Teaching Hospital in Baghdad from 1-1-2016 to 31-12-2016 on 80 pregnant women (40 PROM group with 24-41 week gestation) and (40 pregnant women with similar gestation age without any compliant or complication as a control group) to evaluate the diagnostic power of the vaginal fluid prolactin concentration in premature rupture of membranes. PROM was confirmed by amniotic fluid pooling and Nitrazine paper test. All patients underwent speculum examination for amniotic fluid pooling, Nitrazine paper test, vaginal fluid sampling was done then presence of prolactin in this fluid was measured by ELISA. Levels of vaginal fluid prolactin were shown to be significantly higher (P less than 0.001) in the PROM group when compared with the control group. It can be concluded that Prolactin in cervico-vaginal fluid can indicate pre labor rupture of membranes.