Lactate Dehydrogenase as a Prognosticator in Pregnancy Induced Hypertension

Background: LDH is an intracellular cytoplasmic enzyme which is ubiquitous to all the major organ systems. total serum LDH is highly sensitive but nonspecific test as Serum LDH is abnormal in many disorders. In preeclampsia LDH may be elevated and can indicate the prognosis for both mother and fetus. This study was conducted to assess the relationship between lactate dehydrogenase concentration and the severity of the disease and its complications. Methods: 50 pre-eclamptic women (41 with mild and 9 with severe pre-eclampsia) and 50 healthy normotensive controls were studied prospectively at SREE BALAJI medical college and hospital between January and December 2018. Demographic, hemodynamic and lab data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with fetal outcome were analyzed according to the levels of LDH. Results: Severely pre-eclamptic patients were significantly younger, with low gravidity and parity. LDH levels were significantly elevated in women with preeclampsia and eclampsia (800 IU/l compared with those who had lower levels. Conclusions: Lactate dehydrogenase is a useful biochemical marker that shows the severity of pre-eclampsia. In our study, LDH has been evaluated as a biochemical marker in the prognosis for preeclampsia. Increased levels of LDH require close monitoring and management to prevent maternal and fetal morbidity and mortality.