Two Cases of Multiple Myeloma Revealing 2 Clonal Plasma Cell Populations on Flowcytometry

Flowcytometric immunophenotyping is useful to identify clonal plasma cells which is helpful in the diagnosis of multiple myeloma. The standard diagnostic method involves the selection of abnormal plasma cells by CD38 and CD 138 which is generally positive. We present two cases who were diagnosed with multiple myeloma in the presence of lytic lesions in the skeletal survey and confirmed clonality on flowcytometry, revealing tow populations of plasma cells with positive CD38 and negative CD138 and vice versa respectively.