The Effect of Intravenous Esmolol on Requirement of Desflurane and Post Operative Pain in Laparoscopic Cholecystectomy

Background: The use of -blockers for hemodynamic stability and cardiac protection is well accepted among anaesthesia providers, but recently, researchers have begun to explore the perioperative use of Esmolol as an anaesthetic adjunct. Thus our present study was aimed to observe the effect of intravenous Esmolol on the requirement of Desflurane and analgesic agent for postoperative pain along with its effect on hemodynamic parameters. Method: ASA grade I& II patients (n =188), scheduled for laparoscopic cholecystectomy under general anesthesia, were enrolled for the study. The patients were randomly allocated to one of the two groups A or B according to chit and box method. Group A- Patients received loading dose of injection Esmolol 0.5 mg/kg in 30 ml isotonic saline, 20 min before induction of anesthesia over a period of 5 minutes, followed by an IV infusion of Esmolol 0.05 mg/kg/min till the completion of surgery and Group B- Patients received 30 ml of isotonic saline as loading dose and continuous infusion of isotonic saline at the same rate as the Esmolol group till the completion of surgery. Results: The two groups were comparable with respect to Demographic data. Total consumption of Desflurane was significantly less in group A. Assessment of postoperative pain by Visual Analogue Scale up to 24 hrs showed significant difference in two groups and total dose of analgesic required for pain relief was significantly less (P