Equilibrium Studies on Mixed Ligand Complexes of Drug Ethambutol Hydrochloride with Nickel and Cobalt Metal Ions and Amino Acids

Stability constants of mixed ligand ternary complexes of Co (II) and Ni (II), transition metal ions with ethambutol hydrochloride drug (L) and a series of four amino acids (R) have been determined pH metrically at 300C temperature and 0.1 M ionic strength (NaClO4) in aqueous solution. The formation of various possible species has been evaluated by computer program and discussed in terms of different relative stability parameters