Inhibitory Effectiveness of Jatropha Leaf (Jatropha curcas L.) Extract against Porphyromonas gingivalis Bacteria

Introduction: Gambier (Uncaria gambier Roxb) contains catechins which are functional compounds in the class of polyphenol compounds that have potential as antioxidants and antibacterials. Several factors cause periodontitis, one of which is bacteria and the predominant cause is Porphyromonas gingivalis (P. gingivalis). Objective: The purpose of this study was to determine the effect of gambier extract (Uncaria gambier Roxb. ) on the inhibitory growth of bacteria that cause periodontitis (Porphyromonas gingivalis) and determine the Minimal Inhibitory Concentration (MIC) of gambier extract (Uncaria gambier Roxb) on the growth of bacteria that cause periodontitis (Porphyromonas gingivalis) and determine the minimal inhibitory concentration (MIC) of gambier extract (Uncaria gambier Roxb) Porphyromonas gingivalis. Method: This type of research method used in this study is experimental laboratory research. The research design used is post-test only control group design using the dilution method and disk diffusion method, 50 %, 75 %, 100 %, negative control (distilled water), and positive control (metronidazole). The measuring instrument used in this study is the millimeter (mm) united calipers. Results: The results showed that 15 % MIC began to form inhibitory zones at the growth of Porphyromonas gingivalis of (8.00 � 0.95 mm). The results of the Post Hoc LSD test for the zone of inhibition between treatment groups on the average Porphyromonas gingivalis bacteria showed a significant value (p