Hyperuricemia: Increase Risk of Maternal&Fetal Complications (Outcome) in Preeclampsia

Background - Preeclampsia is a multisystem disorder& most common cause of maternal& fetal death in India& all over the world [1]. Hypertension in pregnancy after 28 wks can cause poor perinatal outcome. Increased serum uric acid level (hyperuricemia) in Preeclampsia [2] further increases risk of complicated pregnancy like premature delivery, foetal distress, maternal& fetal death etc So, increase serum uric acid level is one of the prognostic factor for determination of perinatal outcome. Materials& Methods - 100 Preeclampsia women admitted in OBGY ward after 28 wks of pregnancy were selected as cases& 100 Normotensive pregnant women attending Biochemistry OPD were selected as control (greater than28 wks of pregnancy. Serum Uric acid level was estimated in Biochemistry clinical Laboratory on Autoanalyser in all cases and control& values was compared. Follow up study was taken of Preeclampsia women with hyperuricemia regarding their maternal& fetal outcome till delievery& its outcome was correlated with hyperuricemia. Result � Our study shows increase level of serum uric acid in Preeclampsia compared to Normotensive which is statistically significant ( P value less than 0.05) which shows association of hyperuricemia with Preeclampsia. Current study also shows that there is positive and statistically significant relationship between hyperuricaemia in Preclampsia patients with maternal& fetal outcome. Preeclampsia with hyperuricemia shows increase risk of maternal& fetal complications like PPH, premature deliveries, IUGR, foetal distress etc, resp, which is statistically significant. Conclusion - Preeclampsia is a common cause of maternal death. Hyperuricemia progresses disease, Increase serum uric acid level in Preeclampsia increases risk of maternal& fetal complications& poor perinatal outcome. So early screening for Serum uric acid level must be advised in pregnancy to prevent further risk. Key words: Hyperuricaemia, Preeclampsia, Fetal outcome, Maternal outcome