Nuclear Variations in Urothelial Cells - A Diagnostic Tool in Early Detection of Cervical Carcinoma

Aim: Identification of nuclear variations in exfoliated urothelial cells and cervical smear of the patients undertaken for study. . Materials and Methods: This study included 500 cases with history of risk factors for cervical carcinoma. Cervical smear and urine samples were collected from each patient then processed and stained. Slides were observed under light microscope to detect nuclea variations.500 cells were observed from each sample. Results: The obtained data indicates frequency of various nuclear variations in cervical smears and urine samples are more or less similar. Conclusion: the results obtained as nuclear variations in urothelial cells were significant and almost similar to those of cervical smear cells in identification of genotoxic effects. The urine sample can also be used as an easy, economical and rapid screening test in mass screening programs.