Evaluation of Anti Inflammatory Activity of Benazepril in Albino Rats

EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF BENAZEPRIL IN ALBINO RATS. MEENAMBAL. S1, *ISRAEL RAJA JOHNLEY. I 1. Assistant Professor of Pharmacology, Government Thoothukudi Medical College, Thoothukudi * Assistant Professor of Pharmacology, Government Thoothukudi Medical College, Thoothukudi INTRODUCTION: Inflammation is a component of the biological response of the body to harmful stimuli. Treating inflammation with the (NSAIDs) leads to adverse effects like gastric discomfort, cardiovascular and renal effects. Indomethacin is a NSAID and its mechanism of action is by inhibiting cyclooxygenase nonselectively. Benazepril is an ACE inhibitor and it inhibits angiotensin II molecule formation. Evidence shows, there is an alteration in angiotensin II molecule is implied in the anti inflammatory effect of benazepril and it is found to be lack of the side effects of NSAIDs. Benazepril exerts its anti inflammatory property by acting on intracellular ROS (reactive oxygen species) production in rats with LV hypertrophy by the down regulation of both NF-B and TGF � signaling pathways. Hence, it suggests that benazepril has an anti inflammatory effect. METHODOLOGY: 1 % Carrageenan induced paw edema in rats. RESULTS: Paw volume of control group increased from baseline ( 0.95+ 0.29) to the third hour (3.2+ 0.43). The standard group had a volume of 0.83+0.25 at baseline, and 1.4+ 0.20 at third hour. Similarly, test groups III, IV, V had a paw volume of 0.91+0.26, 0.87+0.26, 0.79+0.33 at baseline and 2.04+ 0.36, 1.8 +0.26, 1.6+ 0.33 at third hour respectively. CONCLUSION: Benazepril exerts its anti inflammatory property by down regulating both NF-B and TGF - signaling pathways and NO-cGMP pathways.