Sudden Onset Severe Headache in a Patient of Aplastic Anaemia Following Bone Marrow Transplantation: A Case Report

10 years old boy from northern india, diagnosed as a case of apastic anaemia diagnosed since 4 months was admitted to Indraprastha Apollo hospitals, New delhi. After a period of chemotherapy and anti-thymocyte globulin, allogenic bone marrow transplantation was done. Just after end of the procedure, he developed headache which became severe after 15 mins post procedure and unresponsive to analgesics. Blood pressure was found to be high. MRI brain showed hyperintensity in bilateral parieto-occipital temporal region. It was diagnosed as posterior reversible encephalopathy syndrome (PRES). Next day of the diagnosis, patient developed seizure which was controlled. Hypertension was managed. Cyclosporin was stopped and mycophenolate mofetil was started. Patient improved symptomatically with prompt management.