Evaluation of Alteration of Serum Uric Acid Level in Hypothyroid and Hyperthyroid Patients in a Tertiary Care Hospital

It has been demonstrated by several studies that thyroid function can affect almost all metabolic activity. Both hypo and hyperthyroidism have potentially fatal systemic manifestations. Hypothyroidism is a clinical syndrome resulting from a deficiency of thyroid hormones which, in turn, results in a generalized slowing down of all metabolic processes. Hypothyroidism is associated with many biochemical abnormalities including increased uric acid levels. Reason behind hyperuricaemia in patients with hyperthyroid status, who are expected to have a higher renal clearance of uric acid may be the increased uric acid production secondary to increased overall metabolism in hyperthyroid patients. According to null hypothesis there is no significant relationship between thyroid status and uric acid level. Justification of this present hospital based non interventional case control study was designed to find any association between uric acid level with hypothyroidism and hyperthyroidism in comparison to normal control. In our study we find that 50 patients of primary hypothyroidism also suffers from hyperuricemia whereas there is also significantly high uric acid level found in primary 31primary hyperthyroid patients in comparison to euthyroid population.