Long Term Morbidity of Polycystic Ovary Patients with Cancer Sequelae

Polycystic ovary syndrome (PCOS) is an invigorating- androgenic disorder affiliated with persistent oligo-anovulation and polycystic ovarian structure, in concordance with psychological impairments, mainly insulin resistance and atoning hyper-insulinemia, which is perceived as leading factor responsible for altered androgen presentation and metabolism. The promising longer term morbidity of PCOS patients with cancer consequences is the focus of research in the present study. This multi- centric study was conducted both retrospectively and prospectively from July 2010 to July 2014. Patients falling under Rotterdam criteria were included in the study at Owaisi Hospital and Research Centre, Princess Esra Hospital and M. H. R. T. , Hyderabad. Women diagnosed with PCOS at the age of 31-40 years has significantly shown 2.3 fold (SIR=2.3, 95 % CI= 1.9-4.3) increased risk of Endometrial Hyperplasia, 41-50 years revealed significant risk (SIR=1.7, 95 % CI= 1.1-2.6). of Endometrial Hyperplasia, whereas 31-40 years showed significant risk (SIR= 2.6, 95 % CI= 1.9-3.1) of Endometrial cancer. In conclusion, women diagnosed with PCOS are at increased risk for endometrial hyperplasia, Endometrial and ovarian cancers. There is a need for research into several unanswered questions in PCOS and for a prototype shift to complexity driven research given the intricacy of PCOS.