Potencial of Salicylic-Acid-Bentonite Clay Nanocomposite as Drug Delivery System and its Characterization of Physichochemical Properties

Synthesis of salicylic acid-bentonite clay nanocomposite by varying the contact time and concentration of salicylic acid has been carried out. The aim of this research is to produce new nanomaterial that has anti-inflammatory activity. The physicochemical properties of this nanocomposite are characterized by X-ray diffraction (XRD), Fourier-Transformation Infrared Spectrofotometry (FTIR), particle size and zeta potential analyzer while the specific surface area, were conducted by Brunauer, Emmet, dan Teller (BET) method. Based on the characterizations it was concluded that the introducing of salicylic acid with different concentration did not give any effect to the crystalinity of the bentonite indicating that the structure of nanocomposite is intercalated. The change of interlayer space as caused by intercalate concentration increasing respectively 16, 95, 16, 40, 16, 63. Characterization of SA-BC nanocomposite by FTIR showed new specific bands indicated intercalation until atomic scale. Band at 1554 cm-1 attributed to vibration of C=C from benzene group. Bands at 1462, 04 cm-1 and 1384, 89 cm-1 indicated anti symetry and simmtry stretching vibration of COO- group of salicylic acid. Bands at 1228, 66 cm-1 and 1109, 07 cm-1 showed vibration of =COO and bending O-H of salicylic acid. Bands at 528, 50 cm-1, 464, 84 cm-1 and 792, 74 cm-1 indicated tetrahedral structure of Si-O-Al, Si-O-Mg, and Fe (III) -OH-Mg respectively. Increasing of zeta potential is caused by intercalation salicylic acid into interlayer of bentonite clay. Zeta potential value of SA-BC nanocomposite 1, 2, 3 are -21, 3 mV, -24, 3 mV, -23, 1 mV, -21, 9 mV respectively. The change of particle size from bentonite into SA-BC nanocomposite 1, 2, 3 respectively are 2211, 8 nm, 777, 4 nm, 2574, 6 nm, and 2007, 1 nm. Decrease of specific surface area is caused by salicylic acid bonded at interlayer and edge surface of bentonite clay. The value of bentonite and SA-BC nanocomposite respectively are 74, 79, 63, 28, 30, 77, 17, 64 m2/g.